Anti-tumor effects of cationic hybrid liposomes against colon carcinoma along with apoptosis in vitro

Biol Pharm Bull. 2012;35(11):2097-101. doi: 10.1248/bpb.b12-00633.

Abstract

New-type three-component cationic hybrid liposomes (HLs) composed of dimyristoylphosphatidylcholine (DMPC), polyoxyethylene(21)dodecyl ether (C(12)(EO)(21)) and O,O'-ditetradecanoyl-N-(α-trimethylammonioacetyl) diethanolamine chloride (2C(14)ECl) were produced. Cationic HLs were smaller and more stable than pure DMPC liposomes. It is noteworthy that cationic HLs could remarkably inhibit the growth of human colon cancer (HCT116) cells along with apoptosis in vitro for the first time in this study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Apoptosis / drug effects
  • Carcinoma
  • Cell Proliferation / drug effects
  • Colonic Neoplasms
  • Dimyristoylphosphatidylcholine / administration & dosage*
  • Dimyristoylphosphatidylcholine / chemistry
  • Ethanolamines / administration & dosage*
  • Ethanolamines / chemistry
  • HCT116 Cells
  • Humans
  • Liposomes
  • Membrane Potential, Mitochondrial / drug effects
  • Myristates / administration & dosage*
  • Myristates / chemistry
  • Polyethylene Glycols / administration & dosage*
  • Polyethylene Glycols / chemistry

Substances

  • Antineoplastic Agents
  • Ethanolamines
  • Liposomes
  • Myristates
  • O,O'-detetradecanoyl-N-(alpha-trimethylammonioacetyl)diethanolamine chloride
  • Polyethylene Glycols
  • Dimyristoylphosphatidylcholine