The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling

Nat Rev Immunol. 2012 Dec;12(12):833-44. doi: 10.1038/nri3325. Epub 2012 Nov 5.


An inflammatory response is initiated when innate immune pattern-recognition receptors (PRRs) expressed by different cell types detect constituents of invading microorganisms and endogenous intracellular molecules released by dying cells. The intracellular cascades activated by PRRs induce the expression and maturation of inflammatory molecules that coordinate the removal of the infectious agents and of the infected or damaged cells. In this Review, we discuss the findings implicating members of the inhibitor of apoptosis protein (IAP) family in the ubiquitylation-dependent regulation of PRR signalling. Understanding the role of IAPs in innate immunity may open new therapeutic perspectives for the treatment of PRR-dependent inflammatory diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / immunology
  • Drosophila melanogaster / enzymology
  • Drosophila melanogaster / immunology
  • Humans
  • Immunity, Innate
  • Inflammasomes / immunology
  • Inflammasomes / metabolism
  • Inhibitor of Apoptosis Proteins / immunology
  • Inhibitor of Apoptosis Proteins / metabolism*
  • Mice
  • Receptors, Pattern Recognition / immunology
  • Receptors, Pattern Recognition / metabolism*
  • Signal Transduction / immunology
  • Signal Transduction / physiology*
  • Toll-Like Receptors / immunology
  • Toll-Like Receptors / metabolism
  • Ubiquitin-Protein Ligases / immunology
  • Ubiquitin-Protein Ligases / metabolism*


  • Inflammasomes
  • Inhibitor of Apoptosis Proteins
  • Receptors, Pattern Recognition
  • Toll-Like Receptors
  • Ubiquitin-Protein Ligases