Rfam 11.0: 10 years of RNA families

Nucleic Acids Res. 2013 Jan;41(Database issue):D226-32. doi: 10.1093/nar/gks1005. Epub 2012 Nov 3.


The Rfam database (available via the website at http://rfam.sanger.ac.uk and through our mirror at http://rfam.janelia.org) is a collection of non-coding RNA families, primarily RNAs with a conserved RNA secondary structure, including both RNA genes and mRNA cis-regulatory elements. Each family is represented by a multiple sequence alignment, predicted secondary structure and covariance model. Here we discuss updates to the database in the latest release, Rfam 11.0, including the introduction of genome-based alignments for large families, the introduction of the Rfam Biomart as well as other user interface improvements. Rfam is available under the Creative Commons Zero license.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Databases, Nucleic Acid*
  • Genomics
  • Internet
  • Molecular Sequence Annotation
  • Nucleic Acid Conformation
  • RNA, Untranslated / chemistry*
  • RNA, Untranslated / classification*
  • RNA, Untranslated / genetics
  • Sequence Alignment
  • User-Computer Interface


  • RNA, Untranslated