Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. Jan-Feb 2013;21(1):55-65.
doi: 10.1111/j.1524-475X.2012.00857.x. Epub 2012 Nov 5.

Topical Application of a Film-Forming Emulgel Dressing That Controls the Release of Stratifin and Acetylsalicylic Acid and Improves/Prevents Hypertrophic Scarring

Affiliations

Topical Application of a Film-Forming Emulgel Dressing That Controls the Release of Stratifin and Acetylsalicylic Acid and Improves/Prevents Hypertrophic Scarring

Elham Rahmani-Neishaboor et al. Wound Repair Regen. .

Abstract

Here, we evaluate the efficacy of an emulgel dressing to control the release of an antifibrogenic factor, stratifin (SFN), along with an anti-inflammatory drug, acetylsalicylic acid (ASA), to be used as a wound dressing with hypertrophic scar reducing features. Emulgel dressings were prepared by dispersing positively charged submicron vesicles in carboxymethyl cellulose gel. Release kinetics of SFN/ASA and toxicity for primary skin cells were assessed in vitro. Antifibrogenic efficacy of medicated emulgel dressings was tested on a rabbit ear fibrotic model. Following topical application on the wounds, emulgels formed an occlusive film and controlled the release of SFN and ASA for 7 and 24 hours, respectively. Wounds treated with SFN/ASA-containing emulgel dressings showed an 80% reduction in scar elevation compared with untreated controls. Topical formulations were nontoxic for cultured human keratinocytes and fibroblasts. Inflammation was significantly controlled in treated wounds, as shown by a reduced number of infiltrated CD3(+) T cells (p < 0.001) and macrophages. SFN/ASA-treated wounds showed a significantly higher (p < 0.001) expression of matrix metalloproteinase-1, resulting in reduced collagen deposition and less scarring. Film-forming emulgel dressings that control the release of antifibrogenic and anti-inflammatory factors provide an excellent treatment option for postburn hypertrophic scar management.

Similar articles

See all similar articles

Cited by 2 articles

Publication types

MeSH terms

Feedback