Response to vitamin D3 supplementation in obese and non-obese Caucasian adolescents

Horm Res Paediatr. 2012;78(4):226-31. doi: 10.1159/000343446. Epub 2012 Oct 31.


Background/aims: Vitamin D deficiency is highly prevalent in obese children, and obese children tend to respond poorly to vitamin D supplementation. The objective of the study was to compare the response to vitamin D(3) supplementation (2,000 IU once daily for 12 weeks) between obese and non-obese Caucasian adolescents.

Methods: The study design was open label non-randomized. It was carried out at a single center. Eighteen obese adolescents (aged 12-18 years) and the same number of age-, gender- and season-matched non-obese adolescents received vitamin D(3) (2,000 IU/day) orally for 12 weeks. Total serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium and phosphorus were measured at baseline and at the end of the 12-week period.

Results: The mean baseline 25(OH)D level was higher in the non-obese compared to the obese subjects (mean 28.9 vs. 25.2 ng/ml; p = 0.029). The increment in 25(OH)D levels following vitamin D supplementation was significantly lower in the obese adolescents (mean change 5.8 vs. 9.8 ng/ml; p = 0.019).

Conclusions: Higher doses of vitamin D are required to treat vitamin D deficiency in obese adolescents compared to their non-obese peers.

Publication types

  • Controlled Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Body Mass Index
  • Child
  • Cholecalciferol / administration & dosage
  • Cholecalciferol / pharmacology*
  • Dietary Supplements
  • Female
  • Humans
  • Ideal Body Weight* / physiology
  • Male
  • Medication Adherence / statistics & numerical data
  • Obesity / complications
  • Obesity / drug therapy*
  • Obesity / epidemiology
  • Obesity / ethnology
  • Prevalence
  • Seasons
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / drug therapy*
  • Vitamin D Deficiency / epidemiology
  • Vitamin D Deficiency / ethnology
  • White People


  • Cholecalciferol