EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies

Future Oncol. 2012 Oct;8(10):1349-59. doi: 10.2217/fon.12.98.


Aim: To determine whether the TKTL1 protein epitope detection in monocytes (EDIM) test allows detection of upregulated glucose metabolism in malignancies.

Materials & methods: The EDIM-TKTL1 blood test was conducted in 240 patients with 17 different confirmed or suspected malignancies. Test scores were compared with (18)F-fluoro-2-deoxy-D-glucose (FDG)-PET/computed tomography (CT) results.

Results: EDIM-TKTL1 score and FDG-PET results showed a concordance of 90% with a sensitivity of 94% and specificity of 81%. Including CT data, all values were enhanced. A subgroup analysis of non-small-cell lung cancer patients showed a significant correlation between the EDIM-TKTL1 score and the primary tumor size determined by FDG-PET/CT.

Conclusion: EDIM-TKTL1 blood test revealed good concordance with FDG-PET/CT results in patients with malignancies demonstrating its efficacy to detect upregulation of glucose metabolism in primary tumors or metastases.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / blood
  • Epitopes / blood
  • Female
  • Glucose / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Monocytes / metabolism*
  • Neoplasms* / blood
  • Neoplasms* / pathology
  • Tomography, X-Ray Computed
  • Transketolase / blood*


  • Biomarkers, Tumor
  • Epitopes
  • TKTL1 protein, human
  • Transketolase
  • Glucose