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. 2013 Apr;124(4):675-85.
doi: 10.1016/j.clinph.2012.10.007. Epub 2012 Nov 4.

Mapping Repetition Suppression of the P50 Evoked Response to the Human Cerebral Cortex

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Free PMC article

Mapping Repetition Suppression of the P50 Evoked Response to the Human Cerebral Cortex

Nash N Boutros et al. Clin Neurophysiol. .
Free PMC article

Abstract

Objective: The cerebral network subserving repetition suppression (RS) of the P50 auditory evoked response as observed using paired-identical-stimulus (S1-S2) paradigms is not well-described.

Methods: We analyzed S1-S2 data from electrodes placed on the cortices of 64 epilepsy patients. We identified regions with maximal amplitude responses to S1 (i.e., stimulus registration), regions with maximal suppression of responses to S2 relative to S1 (i.e., RS), and regions with no or minimal RS 30-80 ms post stimulation.

Results: Several temporal, parietal and cingulate area regions were shown to have significant initial registration activity (i.e., strong P50 response to S1). Moreover, prefrontal, cingulate, and parietal lobe regions not previously proposed to be part of the P50 habituation neural circuitry were found to exhibit significant RS.

Conclusions: The data suggest that the neural network underlying the initial phases of the RS process may include regions not previously thought to be involved like the parietal and cingulate cortexes. In addition, a significant role for the frontal lobe in mediating this function is supported.

Significance: A number of regions of interest are identified through invasive recording that will allow further probing of the RS function using less invasive technology.

Conflict of interest statement

Financial Disclosure: The authors reported no biomedical financial interests or potential conflicts of interest.

Figures

Figure 1
Figure 1
Cortical regions exhibiting the largest amplitude P50s and the grand averages of each region. For abbreviations please refer to Table 1 legend.
Figure 2
Figure 2
The ten cortical regions exhibiting maximal gating of the P50 (dark shaded regions) and the ten regions exhibiting the least gating (light shaded areas) and the evoked responses (S1-thick line and S2-thin line) from each
Figure 3
Figure 3
Topographies of the cortical potentials and estimated current densities for three selected subjects (out of 20) showing differences in cortical potential distributions and generators of S1 signal P50 potential (stimulus registration) and S1-S2 difference waves (sensory gating). Differences are mostly shown in terms of individual regions that are involved in both (subject 15) or predominantly in one of two studied processes such as stimulus registration and repetition suppression (subjects 1 and 19). Data from 20 subjects are shown in the Suplementary Materials section. DW, difference wave; CDR, current density reconstruction.

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