The amorphous pericentriolar cloud takes shape

Nat Cell Biol. 2012 Nov;14(11):1126-8. doi: 10.1038/ncb2617.

Abstract

The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports have now revealed remarkable domain organization within the PCM.

MeSH terms

  • Animals
  • Centrioles / metabolism*
  • Centrosome / metabolism*
  • Humans
  • Microscopy
  • Microtubules / metabolism
  • Models, Biological