Quality Use of Medicines--medication safety issues in naming; look-alike, sound-alike medicine names

Int J Pharm Pract. 2012 Dec;20(6):349-57. doi: 10.1111/j.2042-7174.2012.00210.x. Epub 2012 May 18.


Objective: To review current literature with the objective of developing strategies and recommendations to enhance patient safety and minimise clinical issues with look-alike, sound-alike medication names.

Methods: A comprehensive search of the PubMed database and an Australian online repository of Quality Use of Medicines projects was conducted to identify publications addressing look-alike, sound-alike medication problems. Author networks, grey literature and the reference lists of published articles were also used to identify additional material.

Key findings: Thirty-two publications describing the extent of the specific problem and recommending solutions were identified. The majority of these publications provided a qualitative assessment of the issues, with few quantitative estimates of the severity of the problem and very little intervention research. As a result, most recommendations for addressing the problem are the result of expert deliberations and not experimental research. This will affect the capacity of the recommendations to ameliorate and resolve problems caused by look-alike, sound-alike medication names. Themes identified from articles included the nature and causes of look-alike, sound-alike problems, potential solutions and recommendations.

Conclusions: There are many existing medications which can potentially cause clinical issues due to mix-ups because of similar sounding or looking medication names. This confusion can be lethal for some medication errors. A multifaceted, integrated approach involving all aspects of the medication use process, from initial naming of INN through to consumer education, is suggested to minimise this issue for medication safety.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Drug Labeling
  • Drug-Related Side Effects and Adverse Reactions*
  • Humans
  • Medication Errors / prevention & control*
  • Patient Education as Topic / methods
  • Patient Safety
  • Quality Assurance, Health Care
  • Terminology as Topic*