Acetylcholinesterase inhibitors from the leaves of Macaranga kurzii

J Nat Prod. 2012 Nov 26;75(11):2012-5. doi: 10.1021/np300660y. Epub 2012 Nov 7.

Abstract

Bioassay-guided fractionation of an extract of leaves of Macaranga kurzii yielded four new compounds, a stilbene (furanokurzin, 1) and three flavonoids (macakurzin A-C, 2-4). Nine known compounds were also isolated (5-13). Their structures were determined by spectroscopic analyses including MS and 2D NMR. The isolates were all evaluated for acetylcholinesterase inhibitory activity. Compound 6 (trans-3,5-dimethoxystilbene) exhibited the greatest activity (IC50 9 μM). Cytotoxic evaluation against KB cells showed that compound 7 had an IC50 of 4 μM, followed by 11 (IC50 10 μM) and 3 (IC50 13 μM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cholinesterase Inhibitors* / chemistry
  • Cholinesterase Inhibitors* / isolation & purification
  • Cholinesterase Inhibitors* / pharmacology
  • Drug Screening Assays, Antitumor
  • Euphorbiaceae / chemistry*
  • Flavonoids* / chemistry
  • Flavonoids* / isolation & purification
  • Flavonoids* / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • KB Cells
  • Molecular Structure
  • Plant Leaves / chemistry
  • Stilbenes* / chemistry
  • Stilbenes* / isolation & purification
  • Stilbenes* / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Cholinesterase Inhibitors
  • Flavonoids
  • Stilbenes
  • furanokurzin
  • macakurzi A
  • macakurzi B
  • macakurzi C