SAMHD1 does it again, now in resting T cells

Nat Med. 2012 Nov;18(11):1611-2. doi: 10.1038/nm.2980.

Abstract

A long-standing question in the HIV field is why HIV-1 fails to replicate in resting CD4(+) T cells. A new study shows that host deoxynucleoside triphosphate triphosphohydrolase (dNTPase) sterile α motif and histidine/aspartic domain-containing protein 1 (SAMHD1), previously shown to block HIV infection in myeloid cells, also restricts HIV replication in resting CD4(+) T cells by hydrolyzing dNTPs, which are needed for reverse transcription of the virus (pages 1682-1687).

Publication types

  • Comment

MeSH terms

  • CD4-Positive T-Lymphocytes*
  • HIV-1*
  • Humans
  • Monomeric GTP-Binding Proteins*
  • SAM Domain and HD Domain-Containing Protein 1

Substances

  • SAM Domain and HD Domain-Containing Protein 1
  • SAMHD1 protein, human
  • Monomeric GTP-Binding Proteins