The basic science of dermal fillers: past and present Part I: background and mechanisms of action

J Drugs Dermatol. 2012 Sep;11(9):1059-68.


Dermal fillers have provided a safe and effective means for aesthetic soft tissue augmentation, and have experienced a dramatic increase in popularity during the past 10 years. Much focus has been placed upon filler technique and patient outcomes. However, there is a relative lack of literature reviewing the basic science of dermal fillers, which is vital to a physician's understanding of how each product behaves in vivo. Part I of this article reviews the basic science and evolution of both historical and contemporary dermal fillers; Part II examines their adverse effects. We endeavor to provide the physician with a practical approach to choosing products that maximize both aesthetic outcome and safety.

Publication types

  • Review

MeSH terms

  • Animals
  • Biocompatible Materials / administration & dosage*
  • Cosmetic Techniques*
  • Humans
  • Rejuvenation
  • Skin Aging*
  • Treatment Outcome


  • Biocompatible Materials