A nine-coordinated bismuth(III) complex derived from pentadentate 2,6-diacetylpyridine bis((4)N-methylthiosemicarbazone): crystal structure and both in vitro and in vivo biological evaluation

Inorg Chem. 2012 Nov 19;51(22):12521-6. doi: 10.1021/ic301959z. Epub 2012 Nov 8.

Abstract

Up to now, bismuth(III) complexes with thiosemicarbazones have been comparatively rare. Few in vivo biological studies have been carried out in comparison to the plentiful in vitro data. Here, an interesting nine-coordinated bismuth(III) complex, [Bi(H2L)(NO3)2]NO3 [1; H2L = 2,6-diacetylpyridine bis((4)N-methylthiosemicarbazone)], has been synthesized and structurally characterized. The analytical data reveal the formation of 1:1 (metal/ligand) stoichiometry. In vitro biological studies have indicated that the bismuth complex 1 has shown much higher antibacterial and anticancer activities than its parent ligand, especially with MIC = 10.66 μM against Bacillus cereus and Salmonella typhimurium and IC50 = 26.8 μM against K562 leukemia cells, respectively. More importantly, it also evidently inhibits H22 xenograft tumor growth on tumor-bearing mice (10 mg/kg; inhibitory rate = 61.6%). These results indicate that coordination to bismuth(III) might be an interesting strategy in the discovery of new anticancer drug candidates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Bacillus cereus / drug effects*
  • Bismuth / chemistry*
  • Cell Proliferation / drug effects
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Humans
  • K562 Cells
  • Liver Neoplasms, Experimental / drug therapy*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Structure
  • Salmonella typhimurium / drug effects*
  • Structure-Activity Relationship
  • Thiosemicarbazones / chemistry*

Substances

  • 2,6-diacetylpyridine bis((4)N-methylthiosemicarbazone)
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Coordination Complexes
  • Thiosemicarbazones
  • Bismuth