Exposure to dioxins as a risk factor for soft tissue sarcoma: a population-based case-control study

J Natl Cancer Inst. 1990 Mar 21;82(6):486-90. doi: 10.1093/jnci/82.6.486.

Abstract

In a case-control study including 237 cases with soft tissue sarcoma and 237 controls, previous jobs and exposures to different agents, including pesticides, were assessed. Exposure to phenoxyacetic acids or chlorophenols gave a statistically significant increased rate ratio (RR) of 1.80 [95% confidence interval (CI) = 1.02-3.18] for soft tissue sarcoma. Exposure to phenoxyacetic acids of all types gave a nonsignificantly increased RR of 1.34 (95% CI = 0.70-2.56). During the 1950s, exposure to 2,4,5-trichlorophenoxyacetic acid gave a threefold significantly increased risk. High-grade exposure to chlorophenols, which are also contaminated by dioxins, gave an RR of 5.25 (95% CI = 1.69-16.34). The increased risk was thus attributed to dioxin-contaminated phenoxyacetic acids or chlorophenols that gave an RR of 2.43 (95% CI = 1.30-4.54).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Chlorophenols / toxicity
  • Dioxins / toxicity*
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Middle Aged
  • Phenoxyacetates / toxicity
  • Risk Factors
  • Sarcoma / chemically induced*
  • Surveys and Questionnaires
  • Sweden

Substances

  • Chlorophenols
  • Dioxins
  • Phenoxyacetates