Celsr1-3 cadherins in PCP and brain development

Curr Top Dev Biol. 2012;101:161-83. doi: 10.1016/B978-0-12-394592-1.00010-7.

Abstract

Cadherin EGF LAG seven-pass G-type receptors 1, 2, and 3 (Celsr1-3) form a family of three atypical cadherins with multiple functions in epithelia and in the nervous system. During the past decade, evidence has accumulated for important and distinct roles of Celsr1-3 in planar cell polarity (PCP) and brain development and maintenance. Although the role of Celsr in PCP is conserved from flies to mammals, other functions may be more distantly related, with Celsr working only with one or a subset of the classical PCP partners. Here, we review the literature on Celsr in PCP and neural development, point to several remaining questions, and consider future challenges and possible research trends.

Publication types

  • Review

MeSH terms

  • Alleles
  • Animals
  • Brain / growth & development*
  • Brain / metabolism
  • Cadherins / genetics
  • Cadherins / metabolism*
  • Cell Movement
  • Cell Polarity*
  • Cilia / metabolism
  • Genotype
  • Hair Follicle / cytology
  • Hair Follicle / metabolism
  • Mice
  • Mutation
  • Neurons / cytology
  • Neurons / metabolism
  • Protein Structure, Tertiary
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*

Substances

  • Cadherins
  • Celsr1 protein, mouse
  • Celsr2 protein, mouse
  • Celsr3 protein, mouse
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled