Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk

Elaine Holmes; Jia V Li; Julian R Marchesi; Jeremy K Nicholson

doi:10.1016/j.cmet.2012.10.007

Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk

Cell Metab. 2012 Nov 7;16(5):559-64. doi: 10.1016/j.cmet.2012.10.007.

Authors

Elaine Holmes¹, Jia V Li, Julian R Marchesi, Jeremy K Nicholson

Affiliation

¹ Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

PMID: 23140640
DOI: 10.1016/j.cmet.2012.10.007

Abstract

The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing new personalized therapies and clinical management strategies.

Publication types

Review

MeSH terms

Animals
Bacteria / metabolism*
Bacterial Physiological Phenomena*
Biodiversity*
Diet
Gastrointestinal Diseases / prevention & control
Gastrointestinal Tract / metabolism*
Gastrointestinal Tract / microbiology*
Humans
Metagenome
Metagenomics
Phenotype