Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk

Cell Metab. 2012 Nov 7;16(5):559-64. doi: 10.1016/j.cmet.2012.10.007.


The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing new personalized therapies and clinical management strategies.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteria / metabolism*
  • Bacterial Physiological Phenomena*
  • Biodiversity*
  • Diet
  • Gastrointestinal Diseases / prevention & control
  • Gastrointestinal Tract / metabolism*
  • Gastrointestinal Tract / microbiology*
  • Humans
  • Metagenome
  • Metagenomics
  • Phenotype