AcSDKP, an inhibitor of CFU-S proliferation, is synthesized in mice under steady-state conditions and secreted by bone marrow in long-term culture

Leukemia. 1990 Mar;4(3):235-7.

Abstract

The peptide AcSDKP, isolated from fetal calf bone marrow, is able to prevent DNA synthesis in mouse CFU-S in vivo and in vitro. The molecule is demonstrated here to be constitutively produced in mice and synthesized by bone marrow cells in long term culture.

MeSH terms

  • Animals
  • Bone Marrow / metabolism*
  • Cell Division / drug effects
  • Cells, Cultured
  • Female
  • Hematopoietic Stem Cells / drug effects*
  • Mice
  • Mice, Inbred BALB C
  • Oligopeptides / biosynthesis*
  • Oligopeptides / metabolism

Substances

  • Oligopeptides
  • goralatide