Daddy issues: paternal effects on phenotype

Cell. 2012 Nov 9;151(4):702-708. doi: 10.1016/j.cell.2012.10.020.


The once popular and then heretical idea that ancestral environment can affect the phenotype of future generations is coming back into vogue due to advances in the field of epigenetic inheritance. How paternal environmental conditions influence the phenotype of progeny is now a tractable question, and researchers are exploring potential mechanisms underlying such effects.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Epigenesis, Genetic*
  • Female
  • Gene Expression Regulation*
  • Gene-Environment Interaction*
  • Humans
  • Male
  • Phenotype
  • Plants / genetics