Daddy issues: paternal effects on phenotype

doi:10.1016/j.cell.2012.10.020

. 2012 Nov 9;151(4):702-708.

doi: 10.1016/j.cell.2012.10.020.

Daddy issues: paternal effects on phenotype

Oliver J Rando¹

Affiliations

Affiliation

¹ Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: oliver.rando@umassmed.edu.

PMID: 23141533
PMCID: PMC3564497
DOI: 10.1016/j.cell.2012.10.020

Daddy issues: paternal effects on phenotype

Oliver J Rando. Cell. 2012.

. 2012 Nov 9;151(4):702-708.

doi: 10.1016/j.cell.2012.10.020.

Author

Oliver J Rando¹

Affiliation

¹ Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: oliver.rando@umassmed.edu.

PMID: 23141533
PMCID: PMC3564497
DOI: 10.1016/j.cell.2012.10.020

Abstract

The once popular and then heretical idea that ancestral environment can affect the phenotype of future generations is coming back into vogue due to advances in the field of epigenetic inheritance. How paternal environmental conditions influence the phenotype of progeny is now a tractable question, and researchers are exploring potential mechanisms underlying such effects.

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References

1. Alcazar RM, Lin R, Fire AZ. Transmission dynamics of heritable silencing induced by double-stranded RNA in Caenorhabditis elegans. Genetics. 2008;180:1275–1288. - PMC - PubMed
1. Anderson LM, Riffle L, Wilson R, Travlos GS, Lubomirski MS, Alvord WG. Preconceptional fasting of fathers alters serum glucose in offspring of mice. Nutrition. 2006;22:327–331. - PubMed
1. Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science (New York, NY. 2005;308:1466–1469. - PubMed
1. Arteaga-Vazquez MA, Chandler VL. Paramutation in maize: RNA mediated trans-generational gene silencing. Current opinion in genetics & development. 2010;20:156–163. - PMC - PubMed
1. Avila FW, Sirot LK, LaFlamme BA, Rubinstein CD, Wolfner MF. Insect seminal fluid proteins: identification and function. Annual review of entomology. 2011;56:21–40. - PMC - PubMed

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[1] Alcazar RM, Lin R, Fire AZ. Transmission dynamics of heritable silencing induced by double-stranded RNA in Caenorhabditis elegans. Genetics. 2008;180:1275–1288. - PMC - PubMed

[2] Alcazar RM, Lin R, Fire AZ. Transmission dynamics of heritable silencing induced by double-stranded RNA in Caenorhabditis elegans. Genetics. 2008;180:1275–1288. - PMC - PubMed

[3] Anderson LM, Riffle L, Wilson R, Travlos GS, Lubomirski MS, Alvord WG. Preconceptional fasting of fathers alters serum glucose in offspring of mice. Nutrition. 2006;22:327–331. - PubMed

[4] Anderson LM, Riffle L, Wilson R, Travlos GS, Lubomirski MS, Alvord WG. Preconceptional fasting of fathers alters serum glucose in offspring of mice. Nutrition. 2006;22:327–331. - PubMed

[5] Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science (New York, NY. 2005;308:1466–1469. - PubMed

[6] Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science (New York, NY. 2005;308:1466–1469. - PubMed

[7] Arteaga-Vazquez MA, Chandler VL. Paramutation in maize: RNA mediated trans-generational gene silencing. Current opinion in genetics & development. 2010;20:156–163. - PMC - PubMed

[8] Arteaga-Vazquez MA, Chandler VL. Paramutation in maize: RNA mediated trans-generational gene silencing. Current opinion in genetics & development. 2010;20:156–163. - PMC - PubMed

[9] Avila FW, Sirot LK, LaFlamme BA, Rubinstein CD, Wolfner MF. Insect seminal fluid proteins: identification and function. Annual review of entomology. 2011;56:21–40. - PMC - PubMed

[10] Avila FW, Sirot LK, LaFlamme BA, Rubinstein CD, Wolfner MF. Insect seminal fluid proteins: identification and function. Annual review of entomology. 2011;56:21–40. - PMC - PubMed

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Daddy issues: paternal effects on phenotype

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Daddy issues: paternal effects on phenotype

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