Limb/trunk lean mass ratio as a risk factor for mortality in peritoneal dialysis patients

J Ren Nutr. 2013 Jul;23(4):315-23. doi: 10.1053/j.jrn.2012.09.004. Epub 2012 Nov 8.

Abstract

Background: This study was performed to determine the clinical relevance of limb/trunk lean mass ratio (LTLM) in continuous ambulatory peritoneal dialysis (CAPD) patients.

Methods: This retrospective cohort study included 534 CAPD patients. Body compositions were measured using a dual-energy X-ray absorptiometry apparatus.

Results: In males, the sensitivity and specificity for the diagnosis of sarcopenia were 70.3% and 85.9%, respectively. Respective values in females were 62.3% and 83.8%. The initial low LTLM tertile was associated with mortality in male CAPD patients and in female CAPD patients. Among patients who maintained CAPD for a year, the maintenance of low LTLM tertile was associated with mortality.

Conclusions: LTLM is associated with other lean mass indices, nutritional status, and mortality in CAPD patients. Therefore, LTLM is a novel marker that is useful for the prediction of the nutritional status and mortality in patients with CAPD.

MeSH terms

  • Absorptiometry, Photon
  • Adult
  • Aged
  • Body Composition*
  • Body Mass Index
  • Female
  • Humans
  • Kidney Failure, Chronic / mortality*
  • Linear Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Muscle, Skeletal / metabolism*
  • Nutritional Status
  • Peritoneal Dialysis, Continuous Ambulatory / adverse effects*
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors