Quorum Sensing Inhibitors: An Overview

Biotechnol Adv. Mar-Apr 2013;31(2):224-45. doi: 10.1016/j.biotechadv.2012.10.004. Epub 2012 Nov 9.

Abstract

Excessive and indiscriminate use of antibiotics to treat bacterial infections has lead to the emergence of multiple drug resistant strains. Most infectious diseases are caused by bacteria which proliferate within quorum sensing (QS) mediated biofilms. Efforts to disrupt biofilms have enabled the identification of bioactive molecules produced by prokaryotes and eukaryotes. These molecules act primarily by quenching the QS system. The phenomenon is also termed as quorum quenching (QQ). In addition, synthetic compounds have also been found to be effective in QQ. This review focuses primarily on natural and synthetic quorum sensing inhibitors (QSIs) with the potential for treating bacterial infections. It has been opined that the most versatile prokaryotes to produce QSI are likely to be those, which are generally regarded as safe. Among the eukaryotes, certain legumes and traditional medicinal plants are likely to act as QSIs. Such findings are likely to lead to efficient treatments with much lower doses of drugs especially antibiotics than required at present.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acyl-Butyrolactones / chemistry
  • Acyl-Butyrolactones / pharmacology
  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Aquaculture
  • Aquatic Organisms / metabolism
  • Aquatic Organisms / microbiology
  • Bacteria / drug effects
  • Bacteria / pathogenicity
  • Bacterial Physiological Phenomena*
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism
  • Biofilms / drug effects
  • Host-Pathogen Interactions
  • Humans
  • Plants / metabolism
  • Plants / microbiology
  • Quorum Sensing / drug effects*
  • Repressor Proteins / chemistry
  • Repressor Proteins / metabolism
  • Trans-Activators / chemistry
  • Trans-Activators / metabolism
  • Waste Water

Substances

  • Acyl-Butyrolactones
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • LasR protein, Pseudomonas aeruginosa
  • LuxO protein, Vibrio harveyi
  • QscR protein, Pseudomonas aeruginosa
  • Repressor Proteins
  • Trans-Activators
  • Waste Water
  • LuxR autoinducer binding proteins