EcoCyc: Fusing Model Organism Databases With Systems Biology

Nucleic Acids Res. 2013 Jan;41(Database issue):D605-12. doi: 10.1093/nar/gks1027. Epub 2012 Nov 9.

Abstract

EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E. coli gene products in EcoCyc has been based on information found in the experimental literature for E. coli K-12-derived strains. Updates to EcoCyc content continue to improve the comprehensive picture of E. coli biology. The utility of EcoCyc is enhanced by new tools available on the EcoCyc web site, and the development of EcoCyc as a teaching tool is increasing the impact of the knowledge collected in EcoCyc.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Binding Sites
  • Databases, Genetic*
  • Escherichia coli K12 / genetics*
  • Escherichia coli K12 / metabolism
  • Escherichia coli Proteins / classification
  • Escherichia coli Proteins / metabolism
  • Gene Expression Regulation, Bacterial
  • Internet
  • Membrane Transport Proteins / classification
  • Membrane Transport Proteins / metabolism
  • Models, Genetic
  • Molecular Sequence Annotation
  • Phenotype
  • Position-Specific Scoring Matrices
  • Promoter Regions, Genetic
  • Systems Biology
  • Transcription Factors / metabolism
  • Transcription, Genetic

Substances

  • Escherichia coli Proteins
  • Membrane Transport Proteins
  • Transcription Factors