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. 2013 Mar;139(3):429-35.
doi: 10.1007/s00432-012-1342-8. Epub 2012 Nov 11.

Overexpression of Focal Adhesion Kinase Correlates With Increased Lymph Node Metastasis and Poor Prognosis in Non-Small-Cell Lung Cancer

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Overexpression of Focal Adhesion Kinase Correlates With Increased Lymph Node Metastasis and Poor Prognosis in Non-Small-Cell Lung Cancer

Hong-Fei Ji et al. J Cancer Res Clin Oncol. .

Abstract

Background: The aim of this study was to investigate whether focal adhesion kinase (FAK) overexpression correlates with lymph node metastases and prognosis.

Methods: The protein expression of FAK was investigated in 153 paraffin-embedded tissues by immunohistochemical analysis and then correlated with various clinicopathologic parameters. FAK mRNA level was detected with quantitative RT-PCR in 57 NSCLC frozen tissues and 20 normal matched tissues.

Results: Immunohistochemistry showed FAK overexpression was significantly associated with positive lymph node metastasis and more advanced disease stage of NSCLCs and adenocarcinoma subtype; real-time PCR also indicated a statistically significant correlation between increased FAK mRNA level and the presence of nodal metastases. Moreover, in survival analysis, FAK overexpression was significantly associated with worse overall survival.

Conclusions: FAK overexpression is a promising pathological factor to predict aggressive behavior and prognosis in patients with NSCLC, particularly in the adenocarcinoma subtype.

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