Efficacy and cost of micronutrient treatment of childhood psychosis

BMJ Case Rep. 2012 Nov 9;2012:bcr2012007213. doi: 10.1136/bcr-2012-007213.


Psychosis is difficult to treat effectively with conventional pharmaceuticals, many of which have adverse long-term health consequences. In contrast, there are promising reports from several research groups of micronutrient treatment (vitamins, minerals, amino acids and essential fatty acids) of mood, anxiety and psychosis symptoms using a complex formula that appears to be safe and tolerable. We review previous studies using this formula to treat mental symptoms, and present an 11-year-old boy with a 3-year history of mental illness whose parents chose to transition him from medication to micronutrients. Symptom severity was monitored in three clusters: anxiety, obsessive compulsive disorder and psychosis. Complete remission of psychosis occurred, and severity of anxiety and obsessional symptoms decreased significantly (p<0.001); the improvements are sustained at 4-year follow-up. A cost comparison revealed that micronutrient treatment was <1% of his inpatient mental healthcare. Additional research on broad-spectrum micronutrient treatment is warranted.

Publication types

  • Case Reports

MeSH terms

  • Amino Acids / therapeutic use*
  • Anxiety Disorders / drug therapy*
  • Child
  • Cost-Benefit Analysis
  • Fatty Acids, Essential / therapeutic use*
  • Follow-Up Studies
  • Humans
  • Male
  • Micronutrients / therapeutic use*
  • Minerals / therapeutic use*
  • Obsessive-Compulsive Disorder / drug therapy*
  • Psychotic Disorders / drug therapy*
  • Remission Induction
  • Trace Elements / therapeutic use
  • Treatment Outcome
  • Vitamins / therapeutic use


  • Amino Acids
  • Fatty Acids, Essential
  • Micronutrients
  • Minerals
  • Trace Elements
  • Vitamins