[Usefulness of the Addenbrooke's Cognitive Examination (Spanish version) in Peruvian patients with Alzheimer's disease and Frontotemporal Dementia]

Vertex. 2012 May-Jun;23(103):165-72.
[Article in Spanish]


Introduction: The development of screening tools for the assessment of cognitive status in patients with dementia must be brief yet both highly sensitive and specific in order to ensure its clinical utility. In this sense, it is important to adapt tools widely used around the world to particular populations, allowing for a more proper validity of its use in everyday clinical practice. One of the most popular general cognitive screening tools is the Addenbrooke's Cognitive Examination (ACE), which has been adapted and validated in multiple languages and populations.

Objective: To assess the usefulness of the Peruvian version of the ACE in patients with dementia.

Materials and methods: Healthy controls, patients with Alzheimer disease (AD) and patients with Frontotemporal Dementia (FTD) were assessed with the Peruvian version of the ACE, the ADAScog to determine dementia severity, and a complete neuropsychological battery.

Results: The Peruvian version of the ACE showed very good internal consistency, strong concurrent validity as revealed by significant correlations between the ACE total score and both the MMSE and ADAScog. The ACE was able to differentiate healthy controls from patients with dementia with high discriminatory accuracy. Using a cut-off score of 86 (out of 100), the ACE was exhibited a sensitivity of 100% and a specificity of 100%.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis*
  • Female
  • Frontotemporal Dementia / diagnosis*
  • Humans
  • Language
  • Male
  • Neuropsychological Tests*
  • Peru
  • Prospective Studies