S100A12: a noninvasive marker of inflammation in inflammatory bowel disease

J Dig Dis. 2013 Feb;14(2):62-7. doi: 10.1111/1751-2980.12012.


Inflammatory bowel diseases are incurable conditions that feature gut inflammation. Standard markers have inadequate sensitivity and specificity. S100A12 is a new fecal marker that has promise as a non-invasive indicator of gut inflammation. This article reviews recent studies focusing on S100A12 and highlights the current and potential roles of this biomarker.

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis
  • Biomarkers / metabolism
  • Colitis, Ulcerative / diagnosis
  • Colitis, Ulcerative / metabolism*
  • Crohn Disease / diagnosis
  • Crohn Disease / metabolism*
  • Feces / chemistry*
  • Humans
  • S100 Proteins / analysis*
  • S100 Proteins / metabolism
  • S100A12 Protein


  • Biomarkers
  • S100 Proteins
  • S100A12 Protein
  • S100A12 protein, human