Formulations for trans-tympanic antibiotic delivery

Biomaterials. 2013 Jan;34(4):1281-8. doi: 10.1016/j.biomaterials.2012.10.025. Epub 2012 Nov 9.


We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs--bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / pharmacokinetics*
  • Chinchilla
  • Ciprofloxacin / administration & dosage*
  • Ciprofloxacin / chemistry
  • Ciprofloxacin / pharmacokinetics*
  • Drug Compounding / methods
  • Male
  • Nanocapsules / administration & dosage*
  • Nanocapsules / chemistry
  • Otitis Media / drug therapy*
  • Tympanic Membrane / metabolism*


  • Anti-Bacterial Agents
  • Nanocapsules
  • Ciprofloxacin