Polarity and cell fate asymmetry in Caulobacter crescentus

Curr Opin Microbiol. 2012 Dec;15(6):744-50. doi: 10.1016/j.mib.2012.10.011. Epub 2012 Nov 9.


The production of asymmetric daughter cells is a hallmark of metazoan development and critical to the life cycle of many microbes, including the α-proteobacterium Caulobacter crescentus. For Caulobacter, every cell division is asymmetric, yielding daughter cells with different morphologies and replicative potentials. This asymmetry in daughter cell fate is governed by the response regulator CtrA, a transcription factor that can also bind and silence the origin of replication. CtrA activity is controlled by a complex regulatory circuit that includes several polarly localized histidine kinases. This circuit ensures differential activation of CtrA in daughter cells, leading to their asymmetric replicative potentials. Here, we review progress in elucidating the molecular mechanisms regulating CtrA and the role of cellular polarity in this process.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bacterial Proteins / metabolism
  • Caulobacter crescentus / physiology*
  • Cell Division*
  • Cell Polarity*
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation, Bacterial
  • Signal Transduction
  • Transcription Factors / metabolism


  • Bacterial Proteins
  • CtrA protein, Caulobacter
  • DNA-Binding Proteins
  • Transcription Factors