Revascularization with and without platelet-rich plasma in nonvital, immature, anterior teeth: a pilot clinical study

J Endod. 2012 Dec;38(12):1581-7. doi: 10.1016/j.joen.2012.09.010. Epub 2012 Oct 23.


Introduction: This study was conducted to evaluate and compare maturogenesis induced by revascularization with and without platelet-rich plasma (PRP).

Methods: Twenty patients with nonvital, immature anterior teeth were randomly categorized into 2 groups. Subsequent to chemomechanical preparation, revascularization with and without PRP carried on a collagen sponge was induced in groups 1 and 2, respectively. The cases were followed up clinically and radiographically at 6- and 12-month intervals.

Results: Clinically, all cases were asymptomatic with complete resolution of signs and symptoms. Radiographically, there was a marked difference in periapical healing, apical closure, and dentinal wall thickening in group 2 in comparison with group 1. However, root lengthening was comparable for both of the procedures.

Conclusions: Revascularization is a conservative and an effective method for inducing maturogenesis in nonvital, immature teeth. Supplementations with PRP can potentially improve the desired biological outcome of this regenerative technique.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Apexification / methods*
  • Dentin / diagnostic imaging
  • Female
  • Follow-Up Studies
  • Humans
  • Incisor / pathology
  • Male
  • Neovascularization, Physiologic / physiology*
  • Odontogenesis / physiology
  • Periapical Diseases / therapy
  • Pilot Projects
  • Platelet-Rich Plasma / physiology*
  • Radiography, Bitewing
  • Regeneration / physiology
  • Root Canal Preparation / methods
  • Tissue Scaffolds
  • Tooth Apex / diagnostic imaging
  • Tooth Apex / pathology
  • Tooth, Nonvital / diagnostic imaging
  • Tooth, Nonvital / therapy*
  • Wound Healing / physiology
  • Young Adult