The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development

J Pharm Sci. 2013 Jan;102(1):34-42. doi: 10.1002/jps.23359. Epub 2012 Nov 12.


Biopharmaceutics Classification System and Biopharmaceutics Drug Distribution Classification System are complimentary, not competing, classification systems that aim to improve, simplify, and speed drug development. Although both systems are based on classifying drugs and new molecular entities into four categories using the same solubility criteria, they differ in the criterion for permeability and have different purposes. Here, the details and applications of both systems are reviewed with particular emphasis of their role in drug development.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Absorption
  • Animals
  • Biopharmaceutics / classification*
  • Brain / metabolism
  • Drug Discovery / classification*
  • Drug Interactions
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Hydrogen-Ion Concentration
  • Permeability
  • Pharmaceutical Preparations / chemistry
  • Pharmaceutical Preparations / classification*
  • Pharmaceutical Preparations / metabolism
  • Solubility
  • Terminology as Topic
  • Tissue Distribution


  • Pharmaceutical Preparations