Dendritic cell therapy for Type 1 diabetes suppression

Immunotherapy. 2012 Oct;4(10):1063-74. doi: 10.2217/imt.12.76.

Abstract

While dendritic cell-based therapy is a clinical reality for human malignancies, until now, some conceptual concerns have served to delay its consideration to treat human autoimmune diseases, even in light of almost two decades' worth of overwhelmingly supportive preclinical animal studies. This article provides an overview of the development of dendritic cell-based therapy for Type 1 diabetes mellitus, given that this is the best-studied autoimmune disorder and that there is a good understanding of the underlying immunology. This article also highlights data from the authors' pioneering Phase I clinical trial with tolerogenic dendritic cells, which hopes to motivate the clinical translation of other dendritic cell-based approaches, to one or more carefully selected Type 1 diabetic patient populations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell- and Tissue-Based Therapy*
  • Clinical Trials, Phase I as Topic
  • Dendritic Cells* / immunology
  • Dendritic Cells* / transplantation
  • Diabetes Mellitus, Type 1* / immunology
  • Diabetes Mellitus, Type 1* / therapy
  • Humans
  • Immune Tolerance*