Gazpacho consumption is associated with lower blood pressure and reduced hypertension in a high cardiovascular risk cohort. Cross-sectional study of the PREDIMED trial

Nutr Metab Cardiovasc Dis. 2013 Oct;23(10):944-52. doi: 10.1016/j.numecd.2012.07.008. Epub 2012 Nov 11.


Background and aim: Hypertension is a major public health problem and a leading cause of death and disability in both developed and developing countries, affecting one-quarter of the world's adult population. Our aim was to evaluate whether the consumption of gazpacho, a Mediterranean vegetable-based cold soup rich in phytochemicals, is associated with lower blood pressure (BP) and/or reduced prevalence of hypertension in individuals at high cardiovascular risk.

Methods and results: We selected 3995 individuals (58% women, mean age 67 y) at high cardiovascular risk (81% hypertensive) recruited into the PREDIMED study. BP, weight, and dietary and physical activity data were collected. In multivariate linear regression analyses, after adjustment, moderate and high gazpacho consumption categories were associated with reduced mean systolic BP of -1.9 mm Hg [95% confidence interval (CI): -3.4; -0.6] and -2.6 mm Hg (CI: -4.2; -1.0), respectively, and reduced diastolic BP of -1.5 mm Hg (CI: -2.3; -0.6) and -1.9 mm Hg (CI: -2.8; -1.1). By multiple-adjusted logistic regression analysis, gazpacho consumption was associated with a lower prevalence of hypertension, with OR = 0.85 (CI: 0.73; 0.99) for each 250 g/week increase and OR = 0.73 (CI: 0.55; 0.98) for high gazpacho consumption groups compared to the no-consumption group.

Conclusions: Gazpacho consumption was inversely associated with systolic and diastolic BP and prevalence of hypertension in a cross-sectional Mediterranean population at high cardiovascular risk. The association between gazpacho intake and reduction of BP is probably due to synergy among several bioactive compounds present in the vegetable ingredients used to make the recipe.

Keywords: BP; Blood pressure; CI; DASH; Dietary Approaches to Stop Hypertension; FFQ; Gazpacho (Mediterranean vegetable soup); Hypertension; OR; Odds ratio; PREDIMED; PREDIMED study; Polyphenols; SD; TMD; blood pressure; confidence interval; food frequency questionnaire; prevention with Mediterranean diet study; standard deviations; traditional Mediterranean diet.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging*
  • Blood Pressure
  • Cardiovascular Diseases / epidemiology*
  • Cohort Studies
  • Cooking
  • Cross-Sectional Studies
  • Diet, Mediterranean
  • Female
  • Fruit* / chemistry
  • Functional Food* / analysis
  • Humans
  • Hypertension / diet therapy
  • Hypertension / epidemiology
  • Hypertension / prevention & control*
  • Male
  • Middle Aged
  • Phytochemicals / therapeutic use
  • Prevalence
  • Risk Factors
  • Solanum lycopersicum* / chemistry
  • Spain / epidemiology
  • Vegetables* / chemistry


  • Phytochemicals

Associated data

  • ISRCTN/ISRCTN35739639