Influence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approach

Plant Foods Hum Nutr. 2012 Dec;67(4):415-21. doi: 10.1007/s11130-012-0325-x.


Red pepper spice (RP) and turmeric (TM) are used as flavorings in foods and for medicinal purposes. Utilizing a randomized, doubled-blinded, placebo-controlled, crossover design (2-week washout), 4-week supplementation with RP (1 g/d) or TM (2.8 g/d) was tested for influences on inflammation and oxidative stress in 62 overweight/obese (body mass index ≥ 27 kg/m²) females (40-75 years) with systemic inflammation (C-reactive protein, CRP ≥ 2 mg/l). Overnight, fasted blood samples were collected pre- and post-supplementation, and analyzed for oxidative stress (F₂-isoprostanes, oxidized low density lipoprotein), inflammation (CRP and seven inflammatory cytokines), and metabolic profiles using gas chromatography-mass spectrometry with multivariate partial least square discriminant analysis (PLS-DA). Pre- to post-supplementation measures of inflammation and oxidative stress for both RP and TM did not differ when compared to placebo (all interaction effects, P > 0.05), and global metabolic difference scores calculated through PLS-DA were non-significant (both spices, Q²Y < 0.40). These data indicate that 4-week supplementation with RP or TM at culinary levels does not alter oxidative stress or inflammation in overweight/obese females with systemic inflammation, or cause a significant shift in the global metabolic profile.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Blood Pressure
  • Body Composition / drug effects
  • Body Mass Index
  • C-Reactive Protein / metabolism
  • Capsicum / chemistry*
  • Cross-Over Studies
  • Curcuma / chemistry*
  • Cytokines / blood
  • Dietary Supplements*
  • Double-Blind Method
  • F2-Isoprostanes / blood
  • Female
  • Humans
  • Inflammation / prevention & control
  • Lipoproteins, LDL / blood
  • Metabolomics / methods*
  • Middle Aged
  • Overweight / blood
  • Overweight / drug therapy
  • Oxidative Stress / drug effects
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Spices


  • Biomarkers
  • Cytokines
  • F2-Isoprostanes
  • Lipoproteins, LDL
  • Plant Extracts
  • oxidized low density lipoprotein
  • turmeric extract
  • C-Reactive Protein