Circadian topology of metabolism

Nature. 2012 Nov 15;491(7424):348-56. doi: 10.1038/nature11704.


Biological clocks are genetically encoded oscillators that allow organisms to anticipate changes in the light-dark environment that are tied to the rotation of Earth. Clocks enhance fitness and growth in prokaryotes, and they are expressed throughout the central nervous system and peripheral tissues of multicelled organisms in which they influence sleep, arousal, feeding and metabolism. Biological clocks capture the imagination because of their tie to geophysical time, and tools are now in hand to analyse their function in health and disease at the cellular and molecular level.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Behavior / physiology
  • Biological Clocks / genetics
  • Biological Clocks / physiology*
  • Circadian Rhythm / genetics
  • Circadian Rhythm / physiology*
  • Epigenesis, Genetic
  • Humans
  • Metabolic Diseases / pathology
  • Nervous System Physiological Phenomena