Central nervous system control of metabolism

Nature. 2012 Nov 15;491(7424):357-63. doi: 10.1038/nature11705.


Although it is a widely held thought that direct hormone action on peripheral tissues is sufficient to mediate the control of nutrient handling, the role of the central nervous system in certain aspects of metabolism has long been recognized. Furthermore, recent findings have suggested a more general role for the central nervous system in metabolic control, and have revealed the importance of a number of cues and hypothalamic circuits. The brain's contributions to metabolic control are more readily revealed and play a crucial part in catabolic states or in hormone deficiencies that mimic starvation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autonomic Nervous System / physiology
  • Central Nervous System / metabolism*
  • Energy Metabolism / physiology*
  • Humans
  • Melanocortins / metabolism
  • Neurosecretory Systems / physiology
  • Signal Transduction / physiology


  • Melanocortins