Our aim was to determine the effects of resistance training on cardiovascular risk factors in postmenopausal women. Forty-five women were included in the study. Resistance exercises were done with an intensity of 60% of 1-Repetition Maximum, for 12 weeks. Heart rate, blood pressure, estimated peak VO(2), lipid profiles, and homocysteine levels were evaluated. There were significant time and group interactions for body mass index (p = .02), heart rate (p = .04), systolic blood pressure (p = .03), estimated mean peak VO(2) (p = .00), and total cholesterol (p = .00), but there were no interactions with other evaluated parameters. Resistance training has beneficial effects on particular cardiovascular risk factors in postmenopausal women.