Pyrethroid pesticide exposure and risk of childhood acute lymphocytic leukemia in Shanghai

Environ Sci Technol. 2012 Dec 18;46(24):13480-7. doi: 10.1021/es303362a. Epub 2012 Nov 29.

Abstract

Significant amounts of pyrethroid pesticides are used throughout China. Previous studies have suggested that exposure to pesticides may increase the risk of childhood cancer; however, few studies have focused on pyrethroid metabolites. We investigated five nonspecific metabolites of pyrethroid pesticides found in children's urine and examined the correlation with childhood leukemia. We conducted a hospital-based case-control study of childhood acute lymphocytic leukemia (ALL) in Shanghai between 2010 and 2011. The study included 176 children aged 0-14 years and 180 controls matched for age and sex. Compared with those in the lowest quartiles of total and individual metabolites, the highest quartiles were associated with an approximate 2-fold increased risk of ALL [total metabolites: odds ratio (OR) = 2.75, 95% confidence interval (CI), 1.43-5.29; cis-DCCA: OR = 2.21, 95% CI, 1.16-4.19; trans-DCCA: OR = 2.33, 95% CI, 1.23-4.41; and 3-PBA: OR = 1.84, 95% CI, 1.00-3.38], and most of the positive trends were significant (p < 0.05). Our findings suggest that urinary levels of pyrethroid metabolites may be associated with an elevated risk of childhood ALL and represent a previously unreported quantitative exposure assessment for childhood leukemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Child, Preschool
  • China / epidemiology
  • Confidence Intervals
  • Creatinine / urine
  • Demography
  • Environmental Exposure / analysis*
  • Family Characteristics
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Odds Ratio
  • Pesticides / poisoning*
  • Pesticides / urine
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / urine
  • Pyrethrins / poisoning*
  • Pyrethrins / urine
  • Risk Factors
  • Self Report

Substances

  • Pesticides
  • Pyrethrins
  • Creatinine