IRE1, a double-edged sword in pre-miRNA slicing and cell death

Dev Cell. 2012 Nov 13;23(5):921-3. doi: 10.1016/j.devcel.2012.10.025.


IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote translation of caspase-2.

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