IRE1, a double-edged sword in pre-miRNA slicing and cell death

Justin Hassler; Stewart S Cao; Randal J Kaufman

doi:10.1016/j.devcel.2012.10.025

IRE1, a double-edged sword in pre-miRNA slicing and cell death

Dev Cell. 2012 Nov 13;23(5):921-3. doi: 10.1016/j.devcel.2012.10.025.

Authors

Justin Hassler¹, Stewart S Cao, Randal J Kaufman

Affiliation

¹ Del E. Webb Neuroscience, Aging and Stem Cell Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA.

Abstract

IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote translation of caspase-2.

Publication types

Comment

Abstract

Publication types

Grant support