Respiratory health effects of ambient air pollution: an update

Clin Chest Med. 2012 Dec;33(4):759-69. doi: 10.1016/j.ccm.2012.07.003.


There is new evidence for ambient air pollution (AAP) leading to an increased incidence of respiratory diseases in adults. Research has demonstrated that co-exposures have the potential to dramatically augment the effects of AAP and lower the threshold of effect of a given pollutant. Interactions between genes related to oxidative stress and AAP seem to significantly alter the effect of AAP on an individual and population basis. A better definition of vulnerable populations may bolster local or regional efforts to remediate AAP. Advances in genetic research tools have the potential to identify candidate genes that can guide further research.

Publication types

  • Review

MeSH terms

  • Air Pollution / adverse effects*
  • Gene-Environment Interaction
  • Humans
  • Incidence
  • Particulate Matter / adverse effects*
  • Respiratory Tract Diseases* / epidemiology
  • Respiratory Tract Diseases* / etiology
  • Risk Assessment


  • Particulate Matter