Visfatin and its role in obesity development

Diabetes Metab Syndr. 2012 Apr-Jun;6(2):120-4. doi: 10.1016/j.dsx.2012.08.011. Epub 2012 Aug 30.

Abstract

Visfatin, a product of PBEF gene, is an adipocytokine that harbours strong insulin-mimetic activity and it has been reported previously to associate with obesity. Recent reports also provide evidence that Visfatin has also important intracellular effects as it is homologous with nicotinamide phosphoribosyltransferase (NAMPT). In this review, we summarize the main documented effects of Visfatin on metabolism in humans, with special emphasis put on the pathways associated with obesity.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / metabolism*
  • Cytokines / metabolism
  • Female
  • Humans
  • Inflammation / metabolism*
  • Insulin Resistance*
  • Insulin-Secreting Cells / metabolism
  • Lipids / blood
  • Male
  • Nicotinamide Phosphoribosyltransferase / metabolism*
  • Nicotinamide Phosphoribosyltransferase / pharmacology
  • Obesity / metabolism*

Substances

  • Cytokines
  • Lipids
  • Nicotinamide Phosphoribosyltransferase