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Review
, 324 (1-2), 10-6

Environmental Factors and Their Regulation of Immunity in Multiple Sclerosis

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Review

Environmental Factors and Their Regulation of Immunity in Multiple Sclerosis

Marcus W Koch et al. J Neurol Sci.

Abstract

Epidemiological and clinical studies have shown that environmental factors such as infections, smoking and vitamin D are associated with the risk of developing multiple sclerosis (MS). Some of these factors also play a role in the MS disease course. We are currently beginning to understand how environmental factors may impact immune function in MS on a cellular and molecular level. Here we review epidemiological, clinical and basic immunological studies on the environmental factors, viral and parasitic infections, smoking, and vitamin D and relate epidemiological findings with their likely pathophysiology in MS.

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