Effects of lutein supplement on serum inflammatory cytokines, ApoE and lipid profiles in early atherosclerosis population

J Atheroscler Thromb. 2013;20(2):170-7. doi: 10.5551/jat.14365. Epub 2012 Nov 15.


Aim: The purpose of this study was to determine the effects of lutein supplement on serum cytokines, apoE and lipoprotein profiles in early atherosclerosis population.

Methods: Early atherosclerosis patients (n= 65) were randomized to receive placebo (A+P, n= 31) or 20 mg/d lutein (A+L, n= 34) for 3 months.

Results: Serum lutein increased significantly compared to baseline after lutein supplements in A+L group (p<0.001). Lutein supplements resulted in a significant decrease in serum interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) at 3 month in A+L group (p<0.05). Intragroup comparison revealed a significant difference in the changes of serum MCP-1 between A+L and A+P groups (p= 0.021). The serum low-density lipoprotein (LDL) and triglyceride (TG) significantly decreased in A+L group (p<0.05). The changes in serum lutein were negatively associated with those in serum LDL in A+L group (r=-0.384, p=0.043), while no such relationship was observed in A+P group (r= 0.087, p= 0.685).

Conclusion: An increase in serum lutein after supplementation can reduce inflammatory cytokines and regulate serum lipids, which may pay important roles in early atherosclerosis.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anthropometry
  • Apolipoproteins E / blood*
  • Atherosclerosis / blood*
  • Blood Glucose / analysis
  • Chemokine CCL2 / blood
  • Cholesterol, LDL / blood
  • Cytokines / blood*
  • Diet
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Humans
  • Inflammation
  • Lipids / blood*
  • Lipoproteins, LDL / blood
  • Lutein / therapeutic use*
  • Male
  • Middle Aged
  • Triglycerides / blood


  • Apolipoproteins E
  • Blood Glucose
  • CCL2 protein, human
  • Chemokine CCL2
  • Cholesterol, LDL
  • Cytokines
  • Lipids
  • Lipoproteins, LDL
  • Triglycerides
  • Lutein