Ulcerative colitis associated with isolated unilateral hypoglossal nerve palsy

Intern Med. 2012;51(22):3135-7. doi: 10.2169/internalmedicine.51.8616. Epub 2012 Nov 15.


We herein describe a rare case of ulcerative colitis associated with unilateral hypoglossal nerve palsy. A 64-year-old woman developed severe active ulcerative colitis and was treated with prednisolone. The dose of oral prednisolone was reduced to 7.5 mg/day, following which the patient noticed slight dysphagia and a speech disturbance. She was diagnosed with unilateral hypoglossal nerve palsy, which was thought to be caused by mononeuritis. She was treated with intravenous methylprednisolone at a dose of 500 mg/day, which improved the neuropathy. When the neuropathy occurred, the patient was in a mildly active stage of ulcerative colitis. We concluded that the mononeuritis observed in the present case was likely an extraintestinal manifestation of ulcerative colitis.

Publication types

  • Case Reports

MeSH terms

  • Colitis, Ulcerative / complications*
  • Colitis, Ulcerative / drug therapy
  • Colitis, Ulcerative / pathology
  • Female
  • Humans
  • Hypoglossal Nerve Diseases / complications*
  • Hypoglossal Nerve Diseases / drug therapy
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Prednisolone / therapeutic use


  • Prednisolone
  • Methylprednisolone