Migraine and restless legs syndrome in men

Cephalalgia. 2013 Jan;33(2):130-5. doi: 10.1177/0333102412466965. Epub 2012 Nov 15.


Background: Previous studies suggest an association between migraine and restless legs syndrome (RLS). Population-based data, however, have been limited to women. The aim of this study is to evaluate the association between migraine and RLS in a male cohort.

Methods: We conducted a cross-sectional study among 22,926 participants in the Physicians' Health Study. Migraine and RLS information was self-reported. RLS was classified according to four minimal diagnostic criteria. Age- and multivariable-adjusted logistic regression models were calculated.

Results: Of the 22,926 participants (mean age 67.8), 2816 (12.3%) reported migraine and 1717 (7.5%) RLS. Migraine was associated with an increased multivariable-adjusted odds ratio (OR) (95% confidence interval (CI)) of 1.20 (1.04-1.38) for having RLS. The association remained stable after excluding men with potential mimics of RLS and was not modified by age.

Conclusions: Results of our study indicate an association between migraine and RLS in men. The magnitude of effect is similar to what has been reported in women.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Comorbidity
  • Cross-Sectional Studies
  • France / epidemiology
  • Humans
  • Incidence
  • Male
  • Men's Health / statistics & numerical data*
  • Migraine Disorders / epidemiology*
  • Restless Legs Syndrome / epidemiology*
  • Risk Factors
  • Sex Factors