[An experimental study of the anti-inflammatory action of noopept and its effect on the level of cytokines]

Eksp Klin Farmakol. 2012;75(9):25-7.
[Article in Russian]


The anti-inflammatory effects of noopept (dipeptide analog of piracetam) upon a single intraperitoneal (i.p.) administration at doses of 1, 5, and 10 mg/kg in comparison to the reference drug diclofenac (10 mg/kg, i.p.) have been studied on a model of acute exudative inflammation induced by carrageenan in outbred rats and concanavalin A (Con A) in CBA mice. The level of cytokines was studied on the lipopolysaccharide (LPS) model (single administration, 100 mg/kg, i.p.) with 5-day administration of noopept at a dose of 5 mg/kg (i.p., before endotoxin injection) in C57BL/6 mice. The administration of noopept led to a significant suppression of the inflammatory response to both carrageenan and Con A. The administration of Con A caused a 16-fold increase in the level of IL-6 interleukin in the blood serum of mice as compared to control. Noopept (5 mg/kg) reduced the level of IL-6 by a factor of 1.8 in the inflammatory response to Con A. The administration of LPS led to pronounced increase in the levels ofpro-inflammatory IL-6 and TNF-alpha in the blood serum of test mice as compared to intact animals. The course administration of noopept (5 mg/kg) significantly decreased the level of IL-6 and reduced by half the level of TNF-alpha.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Carrageenan / toxicity
  • Concanavalin A / adverse effects
  • Concanavalin A / pharmacology
  • Cytokines / blood*
  • Diclofenac / pharmacokinetics
  • Dipeptides / pharmacology*
  • Dose-Response Relationship, Drug
  • Inflammation / blood
  • Inflammation / chemically induced
  • Lipopolysaccharides / toxicity
  • Male
  • Mice
  • Mice, Inbred CBA
  • Mitogens / adverse effects
  • Mitogens / pharmacology
  • Rats


  • Anti-Inflammatory Agents, Non-Steroidal
  • Cytokines
  • Dipeptides
  • Lipopolysaccharides
  • Mitogens
  • Concanavalin A
  • Diclofenac
  • ethyl phenylacetyl-Pro-Gly
  • Carrageenan