Non-fouling hydrogels of 2-hydroxyethyl methacrylate and zwitterionic carboxybetaine (meth)acrylamides

Biomacromolecules. 2012 Dec 10;13(12):4164-70. doi: 10.1021/bm301441x. Epub 2012 Nov 16.


Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could be achieved while retaining mechanical properties close to the widely used poly(HEMA) hydrogels. All hydrogels showed an unprecedentedly low fouling from blood plasma. Remarkably, by copolymerization with 10 mol % of carboxybetaine acrylamide, hydrogels fully resistant to blood plasma were prepared.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemical synthesis*
  • Betaine / chemistry
  • Biocompatible Materials / chemistry
  • Humans
  • Hydrogels / chemical synthesis*
  • Methacrylates / chemical synthesis*
  • Plasma / chemistry
  • Polymerization
  • Polymers / chemistry
  • Spectroscopy, Fourier Transform Infrared
  • Surface Plasmon Resonance
  • Surface Properties
  • Water / chemistry


  • Acrylamides
  • Biocompatible Materials
  • Hydrogels
  • Methacrylates
  • Polymers
  • Water
  • Betaine
  • hydroxyethyl methacrylate