Identity crisis: it's not just Foxp3 anymore

Immunity. 2012 Nov 16;37(5):759-61. doi: 10.1016/j.immuni.2012.10.012.


What does it take to make a regulatory T (Treg) cell? In this issue of Immunity, Ohkura et al. show that Treg-cell-specific CpG hypomethylation and Foxp3 expression are independent events required for Treg cell development, stability, and full suppressive activity.

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