Cell biology of infection by Legionella pneumophila

Microbes Infect. 2013 Feb;15(2):157-67. doi: 10.1016/j.micinf.2012.11.001. Epub 2012 Nov 14.


Professional phagocytes digest internalized microorganisms by actively delivering them into the phagolysosomal compartment. Intravacuolar bacterial pathogens have evolved a variety of effective strategies to bypass the default pathway of phagosomal maturation to create a niche permissive for their survival and propagation. Here we discuss recent progress in our understanding of the sophisticated mechanisms used by Legionella pneumophila to survive in phagocytes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bacterial Proteins / metabolism
  • Bacterial Secretion Systems
  • Cell Death
  • Endocytosis
  • Humans
  • Legionella pneumophila / physiology*
  • Legionnaires' Disease / microbiology*
  • Lipid Metabolism
  • Macrophages / microbiology
  • Phagocytes / microbiology
  • Phagocytosis*
  • Phagosomes / microbiology
  • Signal Transduction
  • Ubiquitination


  • Bacterial Proteins
  • Bacterial Secretion Systems