Functional relevance of J-protein family of rice (Oryza sativa)

Cell Stress Chaperones. 2013 May;18(3):321-31. doi: 10.1007/s12192-012-0384-9. Epub 2012 Nov 16.


Protein folding and disaggregation are crucial processes for survival of cells under unfavorable conditions. A network of molecular chaperones supports these processes. Collaborative action of Hsp70 and Hsp100 proteins is an important component of this network. J-proteins/DnaJ members as co-chaperones assist Hsp70. As against 22 DnaJ sequences noted in yeast, rice genome contains 104 J-genes. Rice J-genes were systematically classified into type A (12 sequences), type B (9 sequences), and type C (83 sequences) classes and a scheme of nomenclature of these proteins is proposed. Transcript expression profiles revealed that J-proteins are possibly involved in basal cellular activities, developmental programs, and in stress. Ydj1 is the most abundant J-protein in yeast. Ydj1 deleted yeast cells are nonviable at 37 °C. Two rice ortholog proteins of yeast Ydj1 protein namely OsDjA4 and OsDjA5 successfully rescued the growth defect in mutant yeast. As Hsp70 and J-proteins work in conjunction, it emerges that rice J-proteins can partner with yeast Hsp70 proteins in functioning. It is thus shown that J-protein machine is highly conserved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / genetics
  • Computer Simulation
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Plant
  • Genes, Plant / genetics
  • Genetic Complementation Test
  • Heat-Shock Response / genetics
  • Multigene Family*
  • Mutation / genetics
  • Oryza / genetics*
  • Phylogeny
  • Plant Proteins / genetics
  • Plant Proteins / metabolism*
  • Protein Binding
  • Saccharomyces cerevisiae / genetics
  • Stress, Physiological / genetics
  • Terminology as Topic


  • Plant Proteins