Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Dec;8(4):231-5.
doi: 10.1007/s11523-012-0239-4. Epub 2012 Nov 17.

High Expression of Epithelial Cellular Adhesion Molecule in Peritoneal Metastasis of Gastric Cancer

Affiliations

High Expression of Epithelial Cellular Adhesion Molecule in Peritoneal Metastasis of Gastric Cancer

Motohiro Imano et al. Target Oncol. .

Abstract

Intraperitoneally administrated epithelial cellular adhesion molecule (EpCAM) monoclonal antibody is a therapeutic agent in patients with malignant effusion in several types of carcinoma. However, the role of EpCAM in peritoneal metastasis (PM) lesions and primary lesions of gastric cancer (GC) is still unclear. Therefore, in this study, we investigated EpCAM expression in GC patients with PM. We investigated the expression of EpCAM in 35PM lesions and 104 biopsy samples as primary lesions. Immunohistochemical staining was performed using the Ventana Benchmark XT (Roche Diagnostics) system. EpCAM expression was evaluated by calculating the total immunostaining score, which is the product of the proportion score and the intensity score. Overexpression was defined as a total score greater than 4. All PM specimens showed overexpression of EpCAM, and GC cells in both the surface layer and the deep layer of the PM showed a high expression of EpCAM. Meanwhile, in the biopsy sample, the expression of EpCAM ranged from none to strong. The EpCAM score results for PM specimens and biopsy samples were 11.0 ± 2.0 and 6.9 ± 3.9, respectively. The difference between the scores was statistically significant (P < 0.05). The intraperitoneally administrated EpCAM antibody might have a anti-cancer effect in PM lesions of GC. Additionally, it can be assumed that only GC cells which express a high level of EpCAM might metastasize to the peritoneum.

Similar articles

See all similar articles

Cited by 10 articles

See all "Cited by" articles

References

    1. Dig Dis Sci. 2010 Aug;55(8):2165-71 - PubMed
    1. Anticancer Res. 2012 Sep;32(9):4071-5 - PubMed
    1. J Surg Oncol. 2012 Jan;105(1):43-7 - PubMed
    1. Diagn Cytopathol. 1993 Oct;9(5):516-21 - PubMed
    1. Clin Cancer Res. 2004 May 1;10 (9):3131-6 - PubMed

LinkOut - more resources

Feedback