Similar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase

Angew Chem Int Ed Engl. 2012 Dec 14;51(51):12716-20. doi: 10.1002/anie.201205113. Epub 2012 Nov 19.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / chemistry
  • Acetylcholinesterase / metabolism*
  • Animals
  • Cholinesterase Inhibitors / chemical synthesis
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / metabolism*
  • Crystallography, X-Ray
  • Humans
  • Hydrogen Bonding
  • Ligands
  • Mice
  • Molecular Conformation
  • Protein Binding
  • Protein Structure, Tertiary
  • Stereoisomerism
  • Thermodynamics

Substances

  • Cholinesterase Inhibitors
  • Ligands
  • Acetylcholinesterase